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In addition, due to deterioration in mitochondrial integrity and functions, immunity decreases, and lower levels of melatonin renders older individuals to be more susceptible to impaired redox modulation and age-related diseases

A deeper understanding on how aging, environmental stress and epigenetic regulators shape RPE lipid metabolism may ultimately reveal new therapeutic strategies that preserve PUFA homeostasis, sustain POS renewal and slow degeneration in the diseased eye

Impaired mitophagy prevents the clearance of dysfunctional mitochondria, which continuously produce excessive mtROS and release pro-apoptotic factors

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At appropriate doses, oral supplementation with arginine and glutamine can improve serum protein levels in non-bedridden patients with head and neck cancer after surgery and reduce the incidence of oral mucositis in the radiotherapy subgroup [129, 130] (Fig

However, at later stages, mitophagy is inhibited, leading to severe mitochondrial dysfunction and heart failure