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Recent evidence suggests systemic therapy, either targeted agents or immunotherapy, can be effective in combating BrMs, especially those originating from well-characterized primary tumors ( The establishment of metastatic cancer encompasses entering the central nervous system (CNS) from the blood and crossing the BBB ( Recent accumulating evidence suggests that B cells play a multifaceted and relatively underexplored role in shaping the BrM tumor microenvironment (TME)

FIGURE 8 10 Flavonoids and neurotransmitters Animal studies suggest various flavonoids have anti-inflammatory, antidepressant, and antioxidant properties

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For example, age-dependent hypermethylation of the Klotho gene, a key anti-aging factor, progressively silences its expression, leading to marked reduction or even complete loss of Klotho expression at both mRNA and protein levels, ultimately participating in ARC pathogenesis (237)

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Linking vitamin B1 with cancer cell metabolism