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The accumulation of HNE is thought to have a significant impact on the disruption of metabolic pathways, leading to abnormalities in glucose metabolism, neuronal trafficking, and antioxidant responses (Barone et al

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The WT mice had considerably less DNA adducts (molecules that are strongly bonded to DNA that can lead to DNA breaks and mutations) than the KO mice

Natural compounds can improve the microenvironment by reducing the numbers of regulatory T-cells and tumor-associated macrophages, and thus enhance immune responses

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