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(1996) A multicenter study of sleep-wake rhythm disorders: therapeutic effects of vitamin B12, bright light therapy, chronotherapy and hypnotics

Lippincott.

& Peraza, R

doi: 10.1016/j.parkreldis.2010.02.007 189 YamagishiY.SaigohK.SaitoY.OgawaI.MitsuiY.HamadaY.et al

Together, these studies highlight the complex interplay between CKD, neuroinflammation, and gut-derived signals, providing strong evidence that the gut microbiota and its metabolites play a significant role in promoting neuroinflammatory processes in CKD, which in turn contribute to cognitive decline and neurodegenerative changes