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A ratio of the drug concentration needed to inhibit the test virus relative to that of the reference virus, i.e ., fold change in IC 50 , is reported to denote PI resistance

doi: 10.3389/fimmu.2024.1312919 144 DombrechtEJAertsNESchuerweghAJHagendorensMMEboDGVan OffelJFet al

Additionally, toll-like receptor 4 (TLR4) can induce necroptosis via interaction between the toll receptor-associated activator of interferon (TRIF) and the necrosome (Solon et al., 2024)

10.3969/j.issn.1672-5174.2009.04.020 246 ShenH.LiuX.JiangM.LuoG.WuZ.ChenB.et al (2019)

Biochemistry 13 , 46024608 (1974)

51 New Therapeutic Agents The development of novel therapeutic agents is a challenge, mainly because of the difficulty in designing clinical trials to study the effects of drugs on AD progression, since clinical benefits must be demonstrated in terms of cognitive performance