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(164) used rat insulinoma INS-1 cells as a model of pancreatic glucotoxicity and treated them with 11.2 mM and 22.4 mM glucose for 7 days

Journal of Womens Health, 18(12), 1981-1987

Niciu MJ, Luckenbaugh DA, Ionescu DF, Richards EM, Vande Voort JL, Ballard ED et al (2014b)

Free Radic Biol Med (2019) 133:16268

R., Bass, A

Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]