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Candelario N et al

To bypass the pharmacological challenges associated with unspecific blocking of NMDA receptors, we designed a peptidedrug conjugate comprising the NMDA receptor antagonist MK-801 and a GLP-1 peptide analogue

A relative decline in the efficiency of this potential compensatory mechanism, resulting in a less robust Gln-Glu cycle, may contribute to the manifestation of sensory sensitivity-related symptoms