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Peptides occupy a central position in AD pathobiology: pathogenic species such as A oligomers and tau-derived fragments drive synaptic failure, mitochondrial dysfunction, and neuroinflammation, whereas several endogenous neuropeptides exert compensatory neuroprotective, trophic, or homeostatic effects

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PubMed Anisimov VN, Khavinson VK, Popovich IG, Zabezhinski MA, et al

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The most 3 TSS gives rise to the shorter, major message (GSTF8-S) that is much more stress-responsive than the longer transcript (GSTF8-L) originating from an upstream TSS, which encodes the larger form of the protein

However, lactate levels can increase up to 10 mM in inflammatory pathologies (for example, rheumatic synovial fluid) 48