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Interestingly, direct fibroblast proliferation as measured by cell assay was not significantly affected, suggesting the mechanism is more nuanced than simple cell replication

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Phase III randomized, placebo-controlled, double-blind study of monosialotetrahexosylganglioside for the prevention of oxaliplatin-induced peripheral neurotoxicity in stage II/III colorectal cancer

Extensive research has found that it achieves this by stimulating collagen production, improving skin elasticity while minimizing the appearance of fine lines and wrinkles in mature skin

Under these conditions, the copper-peptide complex remains stable and active

In a similar set of preclinical studies, genistein sensitized the diffuse large cell lymphoma subtype of non-Hodgkin lymphoma to the standard chemotherapeutic combination for this disease (cyclophosphamide, doxorubicin, vincristine, and prednisone), increasing the antitumor effect of the chemotherapy (Mohammad 2003)