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Such an array of SARS-CoV-2 interactions with Hb could induce hemolysis and/or form complexes with released heme, generate dysfunctional Hb (hemoglobinopathy) with reduced ability to transport O 2 /CO 2 and lead to O 2 deprived multi-faceted syndromes, including coagulation disorders 146,150

Strains such as Lactobacillus plantarum and Lactobacillus casei produce antioxidant enzymes (Superoxide dismutase (SOD), glutathione peroxidase - GSH-Px) and exopolysaccharides that scavenge free radicals (442)

RIPA buffer (9806) was from Cell Signaling Technology (Danvers, MA, USA)

Med Hypotheses 110:1522 Santosh TR, Sreekala M, Lalitha K (1999) Oxidative stress during selenium deficiency in seedlings of Trigonella foenum-graecum and mitigation by mimosine part II

Of the two main isoforms of CrK, the cytosolic brain-type CrK and the mitochondrial CrK [168], astrocytes contain predominantly the cytosolic isoform and only little mitochondrial CrK [173]

doi: 10.3945/jn.108.098277 63