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In terms of clinical subtypes, UMN-predominant ALS shows greater cortical hypointensity compared to LMN-dominant forms, indicating specificity in iron distribution (342, 343)

Pediatr Crit Care Med 2001

V-9302 (2-amino-4-bis (aryloxy benzyl) aminobutanoic acid) was originally discovered as an SLC1A5 inhibitor

Basu, S

This could lead to a novel therapeutic strategy for these diseases and their associated complications, including protection for patients with diabetes and obesity related to COVID-19

Novel levodopa formulations and delivery modes address these issues and include novel oral ER formulations as well as non-oral approaches like an inhalation powder for intrapulmonary delivery for on-demand treatment of OFF-episodes and soluble formulations for continuous subcutaneous infusion to control motor fluctuations