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In summary, these results further support the hypothesis that IFN signaling can promote RMC tumor cell state changes, prompting further investigation into the pharmacological inhibition of myeloid-affiliated mediator, p300, which is downstream of IFNGR1

254 Oxidative stress, such as H 2 O 2 in diabetic retinopathy, increases H3K4me3 and H3K27me3 while reducing the acetylation of histones such as H3K9ac and H4K8ac