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doi: 10.1126/scisignal.aau2293 58 YangWSSriRamaratnamRWelschMEShimadaKSkoutaRViswanathanVSet al

doi: 10.1016/j.freeradbiomed.2010.09.006

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Studies have suggested that the mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) has antidepressant effects and that the 5HT2A/2C antagonist ritanserin reverses the antidepressant-like effects of MTEP in TST [93]

However, the best peptide depends on the type of inflammation being addressed

The peptides share structural similarities (both feature the Pro-Gly-Pro tail) and complementary mechanisms that suggest designed synergy