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Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining

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Kobayashi H, Enomoto A, Woods SL, Burt AD, Takahashi M, Worthley DL

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Research on MCL (medial collateral ligament) transection in rats showed BPC-157 restored biomechanical properties to near-normal levels, suggesting potential applications for knee and elbow ligament injuries alongside tendon pathologies