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Cell viability and LDH cytotoxicity assay BHK-21 cells were seeded in 96-well plates, the viability of cells was examined using cell counting kit 8 according to the manufacturers instructions (CCK-8, C0038, Beyotime)

In pancreatic -cells, the highest concentration of zinc is in insulin secretory granules, where it plays a vital role in insulin stability and secretion

Among these proteins, beta-arrestin 1 and 2 are scaffold proteins involved both in desensitization and signal transduction of several GPCRs, including SSTRs and DRD2 (6466)

expression has been also reported in other tissues such as the kidney, lung, placenta, and heart (Zhang et al., 2010)

The main advantages of using hydrophobic tags with APTS systems rather than with affinity chromatography based methods rely on the combination of rapid separation and high capacity with inexpensive costs (Fexby et al., 2004)