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PT-141 therapy may be appropriate for men experiencing erectile dysfunction or reduced sexual desire who want an alternative to traditional oral treatments

For example, the agent may comprise 1, 2, 3, 4, 5 or more or any range therebetween (inclusive) in an amount of an agent that modulates one biomarker or more than one biomarker (e.g., 2 agents that modulate the same target listed in table 1 or table 2, one agent that modulates a target listed in table 1 and a second agent that modulates a target listed in table 2, a combination of an siRNA and an antibody agent that modulates a target listed in table 2, two sirnas that modulate a single target listed in table 1 and a combination of a single siRNA that modulates a single target listed in table 2 and an antibody agent that modulates another target listed in table 2, etc.)

Furthermore, elevated levels of phosphorylated serine 65 of ubiquitin and PRKN have been observed, which are associated with the phosphorylation of ubiquitin by PINK1 at the outer mitochondrial membrane (OMM), have been identified in postmortem PD brains (107)

PMID: 26559695

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An elevated level of Hcy is an independent risk factor associated with dementia [121]