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Analysis of two biological replicates showed that while CO levels were the same in MER3 and mer3-8A strains, there were more NCOs in the mer3-8A strains (Fig

Presumably, the dry skin results from normalization of differentiation and proliferation of the keratinocytes and loosening of their adhesion to one another, thereby resulting in flaky skin.[25] One can also speculate that a topical retinoid would also bind to the sebocytes retinoid receptors, resulting in decreased sebum production, but evidence has yet to exclusively illustrate that topical retinoids are sebosuppressive.[26] Both tazarotene and tretinoin have been reported to reduce facial pore size

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