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Statistical analyses Statistical analyses were conducted using SPSS Statistics software (v.28.0

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For analysis of the RNA-seq data, we performed (1) a classic gene expression analysis to identify differentially expression genes (DEGs) in combination with detection of differential alternative splicing events and (2) the search for the clusters of co-expressed genes by weighted-gene co-expression network analysis (WGCNA)

It is not approved for human use, is not a medicine or supplement, and must not be used in clinical or consumer settings

For instance, elevated glycolysis-induced lactylation of SRY-related high mobility group-box 9 (SOX9), a transcription factor belonging to the SOX family, promotes stemness, migration, and invasion of NSCLC cells