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Quantification and evaluations of catechin hydrate polymeric nanoparticles used in brain targeting for the treatment of epilepsy

10.1023/b:pham.0000045245.21637.d415553238 63 Nakamura M, Fujita K, Toyoda Y, et al

479 A preclinical study indicated that, 480 adjunctive treatment with SG1002 can enhance circulating and tissue levels of H 2 S, alleviating cardiac dysfunction in HFpEF and significantly reducing cardiac interstitial fibrosis

Paralleling the decreases in BH 4 , reductions of eNOS activity were seen of 58, 86, or 92% and NOS-derived superoxide production were greatly increased [15]

Furthermore, a study has investigated targeting the critical calcium dysregulation that occurs between the ER, lysosomes, and mitochondria in Parkinsons disease [81]