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Sepsis: A small RCT in patients with sepsis found that IV NAC (150 mg/kg bolus then 50 mg/kg over 4 hours) improved hepatosplanchnic perfusion, glutathione levels, and liver function markers

This metabolic shift amplifies T cell glycolysis, contributing to excessive activation and subsequent inflammation [123]

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However, it is generally recognized that glutathione is naturally found in the placenta, indicating its essential role in supporting both maternal and fetal health

A combination of mechanisms could have more significant effects on the central mechanisms of migraine