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reported that apatinib reduced the expression of GPX4, thereby inhibiting the proliferation of GC cells and multidrug-resistant GC (Zhao et al., 2021)

These modifications can lead to loss of protein function and cellular dysfunction [177]

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Overexpression resulted in elevated levels of 12-( S )-HETE and 13-( S )-HODE in the mice, leading to several pathological changes: increased AHR, heightened oxidative stress in the mitochondria of bronchial epithelial cells, goblet cell metaplasia, increased sub-epithelial fibrosis, and augmented recruitment of inflammatory cells to the bronchovascular regions

Between his two Nobel Prizes, his peace advocacy, and his sickle cell research, Pauling had become an outright celebrity