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However, through several magnetic resonance spectroscopy studies (MRS) it has been shown that GSH levels are significantly decreased in the hippocampus, frontal, and cingulate cortices early in AD progression (Mandal et al., 2022)

reported the therapeutic potential of another natural quinazoline derivative that promoted oxidative stress and increased ROS production [113]

However, clinically available imaging agents are generally limited by their always on characteristics, which can lead to non-specific imaging interference and false-positive results

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Over the past few decades, various diagnostic frameworks have been established, with the most widely adopted being the 1990 National Institutes of Health (NIH) criteria, the 2003 Rotterdam Consensus, and the 2006 Androgen Excess and PCOS Society (AES) criteria