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Due to the recent shortage of

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IGF-I has been reported to drive B-cell differentiation, to enhance IL-7-dependent B-cell proliferation in parallel with c-kit ligand[171], as well as to potentiate IL-7 promotion of pro-B-cell expansion[166]

Finally, the expression profiling data analysis reinforced GPX4s candidacy by demonstrating its high erythroid specificity, robust expression in whole blood, and marked variability across different physiological and pathological conditions

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