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The activation of the NLRP3 inflammasome is thought to seed and spread the A pathology within and between brain structures (Venegas et al., 2017)

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Nat Rev Drug Discov 8: 579591

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Glutathione is a critical molecule in our bodys defense against oxidative stress and maintaining a robust immune system

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Initially, the carboxylate group on -glutamylcysteine is converted into an acyl phosphate by the transfer of an inorganic phosphate group of ATP to generate an acyl phosphate intermediate

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More than half a decrease in mitochondrial I activity has been observed in patients with sporadic PD and parkin mutations

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SOD1 has been postulated to localize to the outer mitochondrial membrane (OMM), where superoxide anions would be generated, or the intermembrane space

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