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Overall, the metabolomics results of these published cerebrospinal fluid investigations of a wide range of disease conditions did not match our ME/CFS cerebrospinal fluid pattern of disordered serine pathways with sarcosine and phospholipid production, folate and one carbon exchange, purine, pyrimidine, aromatic and anaplerotic amino acid metabolism

*Correspondence: Wim J

On the other hand, GO analysis of the 1,281 genes upregulated on all mutant diets showed enrichment for molecular functions related to monooxygenase, oxidoreductase, UDP-glucosyltransferase, and iron ion binding activities (Fig