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The knowledge about functional expression of transporters at the BBB and structural requirements for substrate binding and translocation via the transporters gives tempting opportunity for rational design and development of drugs, prodrugs and nanocarriers, which can utilize the specific BBB transporter for brain delivery of CNS drugs (71, 72)

Curcumin inhibits TGF-1-induced MMP-9 and invasion through ERK and Smad signaling in breast cancer MDA-MB-231 cells

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"Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+)"

Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models