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Poor sleep can impair this process and increase oxidative stress

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Still, about a quarter of patients have late-onset (after age 25) or very late-onset disease (after age 40), which is associated with a milder course

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Lorente M, Torres S, Salazar M, Carracedo A, Hernandez-Tiedra S, Rodriguez-Fornes F et al (2011) Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action