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40, 41 At one time it was thought that any solution which will not produce a slough when injected perivenously will generally not be strong enough to obliterate a vein. 42 However, some very effective sclerosing solutions are thought to act selectively on damaged varicose endothelium

Some MCD biological activity takes different routes and might be an excellent example of the structure-function link (Figure 2)

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The Risks Translation Gap: From Mice to Humans A persistent challenge across peptide research is the failure of dramatic rodent results to replicate in humans with only 1.5% of positive mouse studies translating to FDA approved therapeutics