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5-Amino-1MQ is supplied as a lyophilised powder and is reconstituted prior to use with sterile bacteriostatic water

Resultant concentration after dilution 50 mL: 0.4 mg/mL To administer: For patients 1 year to 17 years of age, for the 20 mg dose, withdraw 50 mL of the final solution and administer as an I.V

The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested

ECG Recording ECGs were recorded continuously in deeply anesthetized rats for all three main leads, by positioning stainless steel electrodes on all four limbs using an ECG monitor with a 2090 programmer (Medtronic, Minneapolis, MN, USA) connected to a Waverunner LT342 digital oscilloscope (LeCroy, Chestnut Ridge, NY, USA) at 15 min, 24 h or 48 h ligation-time

& Tough, D