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BMC Cardiovasc Disord 6:3 Zheng JS et al (2003) Gene transfer of human guanosine 5-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension

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More importantly, Parkin KO M17 cells were more susceptible to calcium stimulants (e.g., TG), exhibiting increased ER calcium release and elevated mitochondrial calcium levels, which subsequently led to mPTP channel opening and ultimately resulted in cell apoptosis

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