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Both iron deficiency and its excess may lead to disturbances in fundamental metabolic processes, highlighting the need for tight regulation within tissues [10]

The mechanisms by which IGF-I reverses and/or prevents microvascular rarefaction and improves tissue blood supply are likely multifaceted, and may involve, among others: 1) Apoptosis, since IGF-I inhibits oxidative stress-induced apoptosis by preserving the functional integrity of the mitochondria[56, 290]

The LSMBO team develops innovative methodologies in chromatography, mass spectrometry (MS) and bioinformatics for : Functional proteomic analysis for the identification and quantification of thousands of proteins in complex biological matrices (sample preparation, targeted (PRM) and global (DIA) quantitative LC-MS/MS analysis, statistical analysis and integration of multi-omics data)

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66, 67, 68, 69 In contrast, when renal arterial pressure was servo-controlled, Ang II infusion at all infusion rates (51215 ng kg 1 min 1 , i.v.) in the same dogs decreased urinary sodium excretion