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Additionally, diminished expression of soluble guanylate cyclase (sGC), the target of NO, in asthmatic airway epithelial cells leads to depletion of cGMP needed for bronchorelaxation (98)

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Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, transient elevations in serum amylase, and opioid-induced esophageal dysfunction (OIED)

2.2 Parkinson's disease (PD) PD patients show exhaustive gut microbiome dysbiosis, such as reduced Prevotella and increased Enterobacteriaceae, which can be related to GI symptoms such as constipation (Hashish and Salama, 2023)