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Recently, the importance of the integrity of the choriocapillaris in all three clinical sub-types of AMD has been brought to the light with seminal studies demonstrating its vulnerability in non-neovascular or dry AMD (Mullins et al., 2011), while OCTA studies indicate thinning of the choroid, concomitant with increased average choriocapillaris signal void size, compared to eyes without neovascular AMD (McLeod et al., 2009)

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In contrast, several studies included in this review that enrolled younger individuals or participants with milder symptom profile have documented improvements following EPA/DHA supplementation, suggesting that age, developmental stage, and baseline severity may critically modulate treatment responsiveness