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NMO is mainly caused by auto-anti-AQP4 antibodies 282 that initially attack astrocytic endfeet, 283 leading to complement-mediated lysis and destruction of the glial limitans and astrocyte degeneration, which in turn cause the other pathophysiological sequalae (Fig

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For the individuals with ASD identified from 19902019, the lifetime social (medical, educational, productivity, and care) cost for the US was estimated to be more than $7 trillion in 2019 dollars [80]

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