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Pharmacol Rep 65(5):12721280 Corso L et al (2016) Saffron reduces ATP-induced retinal cytotoxicity by targeting P2X7 receptors

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In this study, we examine how diminished GPX4 function may be a critical event in triggering oxytosis/ferroptosis to perpetuate or initiate the neurodegenerative diseases and assess the possible therapeutic importance of oxytosis/ferroptosis in neurodegenerative disorders

In individuals with AA, lesions typically appear in sequence, and multiple patches may develop simultaneously