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Abbreviations ACC: Acetyl-CoA carboxylase CD36: Cluster of differentiation 36 CKD: Chronic kidney disease CoA: Acyl coenzyme A CPT1A: Carnitine palmitoyltransferase 1 DN: Diabetic nephropathy ECM: Extracellular matrix EMT: Epithelialmesenchymal transition ESRD: End-stage renal disease ESRRA: Estrogen-related receptor alpha FAO: Fatty acid oxidation FAS: Fatty acid synthase MF: Myofibroblasts PGC-1: Peroxisome proliferator-activated receptor coactivator 1 PPAR: Peroxisome proliferator-activated receptor RF: Renal fibrosis SCFAs: Short-chain fatty acids SIRT1: Sirtuin 1 STAT6: Signal transducer and activator of transcription 6 TCM: Traditional Chinese medicine TWIST1: Twist-related protein 1 References Djudjaj S, Boor P

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2 The PLATINO (Proyecto Latino Americano de Investigacion en Obstruccion Pulmonar) study estimated the prevalence of CB as 7.8% to 19.7% in 5 major cities in South America

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This results in a decrease in storage capacity and, as a consequence, depletion of monoamines in the brain and the peripheral nervous system

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