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second, that this shift is enabled through new forms of networked governance and discretionary decision-making that circumvent traditional planning instruments

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Notably, BACH1 is traditionally recognized as an angiogenesis inhibitor that regulates HO-1 or VEGF transcription

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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

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Roth CL, McCormack SE

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No published Phase I trial establishing tolerability, human pharmacokinetics or dose escalation was identified

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