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2021;10:e2000549

R.FerrisJ

When the authors considered the subgroup analysis with intervention patients using 12g L-carnitine in both RCTs, we did not observe a statistical difference (DR = -0.06

Results The interaction test yielded no significant differences between the effects of the four daily oral maintenance dosages of L-carnitine (i.e., 2 g, 3 g, 4 g, and 6 g) on all-cause mortality (risk ratio [RR] = 0.77, 95% CI [0.57-1.03], P = 0.08) with a statistically insignificant trend favoring the 3 g dose (RR = 0.48) over the lower 2 g dose (RR = 0.62), which was favored over the higher 4 g and 6 g doses (RR = 0.78, 0.78)

Informed consent was obtained from all study participants

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