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[371] Given the limited applicability of the trials' exclusion criteria to many RP patients, it's unlikely that future trials will include such individuals

60,67,71,72,73 Further research found that AN extract induces the transformation of fibroblasts into MFBs through multiple molecular mechanisms, including activation of PLC/IP3/Ca2 + and Rho kinase regulating cell contraction, as well as direct phosphorylation by NF-B, JNK, P38 MAPK mediating CTGF production

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