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In this process, GSH is constantly oxidized to GSSG by the enzyme glutathione peroxidase.To maintain the intracellular redox balance, GSH is replenished through the reduction GSSG by glutathione reductase enzyme

Amino acid transporter Slc38a5 controls glucagon receptor inhibition-induced pancreatic cell hyperplasia in mice

Inhibition of autophagy and chemokine induction by sphingosine 1-phosphate receptor 1 through NF-kappaB signaling in human pulmonary endothelial cells infected with influenza A viruses

Compounds targeting ferroptosissuch as iron chelators, lipid peroxidation inhibitors, antioxidants, and radical scavengersmay exert their neuroprotective effects by modulating iron metabolism, lipid oxidation, and redox homeostasis (18, 114, 225235)

Further studies with TRIM5 showed that it also interacted with ATG14L1 and AMBRA1, both proteins that interact with the Beclin 1 complex