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But heres the key: over-supplementing long-term can cause the body to become dependent and reduce its own natural production

PLoS One 15 , e0234484 (2020)

TGF- in developmental and fibrogenic EMTs

Similarly, oral acute toxicity tests at 3,000 mg/kg and 5,000 mg/kg resulted in no deaths, suggesting an LD 50 greater than 5,000 mg/kg, classifying it as practically non-toxic and safe (709)

Biogerontology 8:469482 Knight JA, Smith SE, Kinder VE, Anstal HB (1987) Reference intervals for plasma lipoperoxides: age-, sex, and specimen-related variations