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309 This pathway allows cells to adapt to varying oxygen levels by regulating essential proteins, potentially including the proinflammatory cytokine interleukin-32 (IL-32), which is also degraded via this mechanism

All intermediates and final products were characterized using 1 H NMR spectroscopy, 13 C NMR spectroscopy, and high-resolution mass spectrometry (Supplementary Figs

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On the other hand, clinical studies demonstrate that polyphenols such as resveratrol, genistein, daidzein, and equol, a metabolite of daidzein naturally produced by bacteria in the gut of some individuals, improve bone health by increasing body bone mineral density (BMD) (especially of the lumbar spine, femoral colon, and total hip), due to their estrogenic activity