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Rapid reduction or abrupt discontinuation of opioid analgesics in patients who are physically dependent on opioids has resulted in serious withdrawal symptoms, uncontrolled pain, and suicide

In the lipid-rich environment of the CNS, ferroptosis could therefore play a significant role in secondary damage, the neuron-astrocyte interaction is also critical for maintaining brain lipid metabolism, indicating that neurons may be more sensitive to drastic changes in lipid peroxidation, moreover, lipid peroxidation contributes to secondary damage after SCI and highlights the possible use of lipid metabolism regulator to treat SCI [46,47,48]

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In models of pre-existing oxidative stress or injury, CGAs potent antioxidant properties are therapeutic (Figure 9)

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The pH titration experiments were performed in 100 mM HEPES, 150 mM NaCl 2 , 0.5 mM MgCl 2 and pH between 6 and 9 adjusted by KOH, with the actual pH measured post-hoc