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Nanotechnology improves the solubility and bioavailability of therapeutic agents, enables controlled and targeted delivery to hepatocytes, and supports multifunctional therapeutic strategies tailored to HBV and HCV infections

Autophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidus

The adaptor protein DDB1 (DNA damaging-binding protein 1) binds CULLIN4A/B-RBX1 complex and interacts with multiple WD40-repeat proteins (WDRs) to regulate cell cycle progression and DNA damage response 8

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The most serious risk, lactic acidosis, is extremely rare (estimated at 1-5 cases per 100,000 patient-years) and occurs almost exclusively in patients with severe kidney impairment or acute illness