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Quick Answer: GLP-1 receptor agonist-related fatigue likely results from multiple indirect mechanisms including substantial caloric restriction, gastrointestinal side effects causing dehydration and nutritional deficits, and metabolic adaptation during weight loss, rather than a single direct pharmacological effect

Some suggest splitting doses, others insist on single morning administration

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10.1016/j.imlet.2018.11.007 4

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Therefore, it is not appropriate most -- especially those who are pregnant, breastfeeding, have active cancer, or certain metabolic conditions