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Its surface is characterized by a predominantly positive charge at the inward entrance and a hydrophobic profile at the cavity apex (Fig

10.1111/j.1572-0241.1999.00797.x 156

Interestingly, GSTO1 was identified as one of the potential cellular targets of piperlongumine, an electrophilic compound exerting selective cytotoxicity against cancer cells through an oxidative cell death mechanism (Supplementary Table 25) 37

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