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Funding acquisition: HK and AA

The independence of and associations among apoptosis, autophagy, and necrosis

Luan Y, Luan Y, Yuan RX, Feng Q, Chen X, Yang Y (2021) Structure and function of mitochondria-associated endoplasmic reticulum membranes (MAMs) and their role in cardiovascular diseases

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A study (Dixon et al., 2012) has found that using shRNA to knock down G6PD or 6PGD in cells or using specific inhibitors of the PPP pathway, such as 6-aminonicotinamide (6-AN), can significantly inhibit erastin-induced ferroptosis, suggesting that NADPH produced by the PPP pathway may promote ferroptosis

Senolytic agents include natural compounds such as quercetin 13 or fisetin 14 , -galactosidase-activated nanoparticles and prodrugs 15,16,17 or compounds that target different vulnerabilities of senescent cells, such as HSP90 inhibitors 18 , cardiac glycosides 19,20 or NMT inhibitors 21