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4A, B and S4A, B), an effect abrogated by Fer-1, a ferroptosis inhibitor, but not by apoptosis (ZVAD-FMK) or necroptosis (necrostatin-1, Nec-1) inhibitors (Fig

The general reaction involves formation of an unsymmetrical disulfide from the protectable protein (RSH) and GSH: [24] RSH + GSH + [O] GSSR + H 2 O Glutathione is also employed for the detoxification of methylglyoxal and formaldehyde, toxic metabolites produced under oxidative stress

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