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Best practices for generating and using alpha-synuclein pre-formed fibrils to model parkinsons disease in rodents

The predominantly unstructured conformation of -syn makes it a target for various post-translational modifications such as phosphorylation

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doi:10.1016/j.tibs.2019.04.001

Although the overall disease progression of NAFLD has been characterized, the exact mechanism(s) underlying its initiation and progression remain poorly defined

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