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Cohort demographics and clinical diagnostic categories are summarized in Supplementary Table 1

Net Weight: 160g

Funding This study was supported by the funding of the National Natural Science Foundation of China (81871000 and 81901294), the China Postdoctoral Science Foundation (2019M653424), the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYJC18038), the National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University (Grant No

Of 500 genes on chromosome 21, 18 genes influence gene expression, and more than 20 genes are involved in metabolic functioning (Sturgeon and Gardiner 2011)

Adding a GST-tag to a protein's N-terminus can facilitate its detection, isolation, and purification by GSH affinity resin